Ka Yang

Junior PIka_yang@szbl.ac.cn

Yangresearchgroup.org

Educational background&Work experience

2026-Present     Junior PI, Shenzhen Bay Laboratory, 
2022-2026         Postdoctoral Fellow, Harvard Medical School
2020-2022         Postdoctoral Fellow, St. Jude Children's Research Hospital
2019-2020         Postdoctoral Fellow, University of Wisconsin–Madison
2014-2019         Ph.D., University of Wisconsin–Madison
2009-2013         Bachelor's Degree, Tianjin University

Research field

“Hard-to-drug” proteins lack clear ligandable sites, dynamic regulatory mechanisms, and effective intervention tools, representing a major bottleneck in innovative drug discovery. Focusing on the question of "how to discover small-molecule-regulatable functional sites and intervene in protein homeostasis at the proteomic scale," the research group has developed a research strategy of "site discovery—mechanism elucidation—chemical modulation." By applying technologies including high-throughput chemical proteomics, targeted protein degradation, and bioinformatics, the group focuses on identifying and validating new drug targets/sites, exploring the ligandability of undruggable targets, and discovering bioactive small molecules for the treatment of disease.